Rat Brain Glutathione S-transferasespotentially Defends Acrylamide Induced Neurotoxicity and Genotoxicity

Acrylamide (AC) is a noxious chemical and it is widely used in this modernized world. There by this study aimedto assess the acrylamide induced neurotoxicity and genotoxicityonmale wistar rat brain. Based on the study aim, male at brainwas exposed by short term and long term to acrylamide and investigated the crucial changes in glutathione S-transferases and its associated glutathione peroxidase activities including degradation of DNA. Significant alterations of glutathione S-transferases and its associated glutathione peroxidase activities andinjured DNA results were documented. This study revealed that the glutathione S-transferases are potentially defends acrylamide toxicity to some extent but their activities aresignificantly decreasedby the accumulation of acrylamidein the brain and leads to degradation of DNA.